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oci aml3  (DSMZ)


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    DSMZ oci aml3
    The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B <t>),</t> <t>OCI-AML3</t> ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated
    Oci Aml3, supplied by DSMZ, used in various techniques. Bioz Stars score: 96/100, based on 539 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/oci+aml3/OCI-AML3/pmc13032267-47-16-23
    Average 96 stars, based on 539 article reviews
    oci aml3 - by Bioz Stars, 2026-09
    96/100 stars

    Images

    1) Product Images from "RGX-019-MMAE inhibits leukemia progression by targeting MER proto-oncogene tyrosine kinase (MERTK) in acute myeloid leukemia"

    Article Title: RGX-019-MMAE inhibits leukemia progression by targeting MER proto-oncogene tyrosine kinase (MERTK) in acute myeloid leukemia

    Journal: Journal of Experimental & Clinical Cancer Research : CR

    doi: 10.1186/s13046-026-03657-y

    The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B ), OCI-AML3 ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated
    Figure Legend Snippet: The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B ), OCI-AML3 ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated

    Techniques Used: Activity Assay, Expressing, Staining, Flow Cytometry

    RGX-019-MMAE in combination with venetoclax enhanced AML cell killing. A , B Bar graphs show the absolute count of live leukemic cells in OCI-AML3 ( A ) and THP-1 ( B ) cell lines treated with indicated concentrations of venetoclax, RGX-019, and/or RGX-019-MMAE. Flow cytometry was used to determine the combinatorial effects of RGX-019-MMAE or monoclonal antibody RGX-019 with venetoclax. Annexin V-FITC was used as an apoptosis marker, and cell viability was determined with DAPI. (Welch one-way ANOVA) * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001
    Figure Legend Snippet: RGX-019-MMAE in combination with venetoclax enhanced AML cell killing. A , B Bar graphs show the absolute count of live leukemic cells in OCI-AML3 ( A ) and THP-1 ( B ) cell lines treated with indicated concentrations of venetoclax, RGX-019, and/or RGX-019-MMAE. Flow cytometry was used to determine the combinatorial effects of RGX-019-MMAE or monoclonal antibody RGX-019 with venetoclax. Annexin V-FITC was used as an apoptosis marker, and cell viability was determined with DAPI. (Welch one-way ANOVA) * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001

    Techniques Used: Flow Cytometry, Marker

    Related Articles

    Cell Culture:

    Article Title: The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy
    Article Snippet: Both cell models were cultured at 37°C in a humidified incubator with ambient air and 5% CO 2 in RPMI1640 medium (ThermoFisher, 31870074) supplemented with 10% fetal bovine serum (FBS; Sigma Aldrich, F7524), 100 I.U./mL penicillin-100 μg/mL streptomycin (ThermoFisher, 15140122), 2 mM L-glutamine (Fisher Scientific, 11510626), 20 ng/mL recombinant mouse stem cell factor, 10 ng/mL recombinant mouse interleukin 3 and 10 ng/mL recombinant mouse interleukin 6 (BioLegend Europe BV, 579708, 575708, 575508). .. U937, NB4, MV4–11, MOLM14, OCI-AML3, NOMO-1 and MONOMAC6 (MM6) human AML cell lines were obtained from the Leibniz Institute DSMZ and cultured at 37°C in a humidified incubator with ambient air and 5% CO 2 in RPMI1640 medium supplemented with 10% FBS, 100 I.U./mL penicillin-100 μg/mL streptomycin and 2 mM L-glutamine. .. Cell line identity was validated by DNA fingerprinting and cultures were tested for mycoplasma contamination every six months using a Mycoplasma PCR Detection Kit (Abcam, ab289834).

    Article Title: High-throughput ligand diversification to discover chemical inducers of proximity.
    Article Snippet: .. OCI-AML2 (gift from J. Bradner), OCI-AML3 (German Collection of Microorganisms and Cell Cultures (DSMZ), ACC 582) and Kasumi-1 (American Type Culture Collection (ATCC), CRL-2724) were cultured in 20% FBS in RPMI 1640. .. HB11;19 (gift from the laboratory of A. Yokoyama), Jurkat (gift of the laboratory of M. Bollong) MV4;11 and MOLM-13 (gifts from J. Bradner), NALM6 (given by ChemoGenix, University of Montreal) and EOL1 (DSMZ, ACC 386) cells were cultured in 10% FBS in RPMI 1640.

    Article Title: The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy.
    Article Snippet: Both cell models were cultured at 37°C in a humidified incubator with ambient air and 5% CO 2 in RPMI1640 medium (ThermoFisher, 31870074) supplemented with 10% fetal bovine serum (FBS; Sigma Aldrich, F7524), 100 I.U./mL penicillin-100 μg/mL streptomycin (ThermoFisher, 15140122), 2 mM L-glutamine (Fisher Scientific, 11510626), 20 ng/mL recombinant mouse stem cell factor, 10 ng/mL recombinant mouse interleukin 3 and 10 ng/mL recombinant mouse interleukin 6 (BioLegend Europe BV, 579708, 575708, 575508). .. U937, NB4, MV4–11, MOLM14, OCI-AML3, NOMO-1 and MONOMAC6 (MM6) human AML cell lines were obtained from the Leibniz Institute DSMZ and cultured at 37°C in a humidified incubator with ambient air and 5% CO 2 in RPMI1640 medium supplemented with 10% FBS, 100 I.U./mL penicillin-100 μg/mL streptomy- cin and 2 mM L-glutamine. .. Cell line identity was validated by DNA fingerprinting and cultures were tested for mycoplasma contamination every six months using a Mycoplasma PCR Detection Kit (Abcam, ab289834).



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    The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B <t>),</t> <t>OCI-AML3</t> ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated
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    The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B <t>),</t> <t>OCI-AML3</t> ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated
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    Image Search Results


    The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B ), OCI-AML3 ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated

    Journal: Journal of Experimental & Clinical Cancer Research : CR

    Article Title: RGX-019-MMAE inhibits leukemia progression by targeting MER proto-oncogene tyrosine kinase (MERTK) in acute myeloid leukemia

    doi: 10.1186/s13046-026-03657-y

    Figure Lengend Snippet: The antibody-drug conjugate RGX-019-MMAE induced cytotoxic activity in MERTK-expressing AML cell lines. A MERTK expression in the indicated AML cell lines; leukemic cells (1 × 10 6 ) were stained with anti-MERTK-APC antibody, and the expression was measured by flow cytometry. Data are plotted as mean values with error bars representing standard error. B - F Bar graph showing the percentage of relative luminescence in Kasumi 1 ( B ), OCI-AML3 ( C ), MOLM-13 ( D ), MOLM-14 ( E ), and MV4-11 ( F ) cells treated with the indicated concentrations of RGX-019-MMAE and monoclonal antibody RGX-019. Data are plotted as mean values with error bars representing standard error (Student unpaired t -test). * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001. UT = untreated

    Article Snippet: Kasumi-1, THP-1, MV4-11, and U937 AML cells were purchased from ATCC (Manassas, VA), and MOLM-13, MOLM-14, OCI-AML3, and OCI-AML2 cells were obtained from DSMZ (Braunschweig, Germany).

    Techniques: Activity Assay, Expressing, Staining, Flow Cytometry

    RGX-019-MMAE in combination with venetoclax enhanced AML cell killing. A , B Bar graphs show the absolute count of live leukemic cells in OCI-AML3 ( A ) and THP-1 ( B ) cell lines treated with indicated concentrations of venetoclax, RGX-019, and/or RGX-019-MMAE. Flow cytometry was used to determine the combinatorial effects of RGX-019-MMAE or monoclonal antibody RGX-019 with venetoclax. Annexin V-FITC was used as an apoptosis marker, and cell viability was determined with DAPI. (Welch one-way ANOVA) * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001

    Journal: Journal of Experimental & Clinical Cancer Research : CR

    Article Title: RGX-019-MMAE inhibits leukemia progression by targeting MER proto-oncogene tyrosine kinase (MERTK) in acute myeloid leukemia

    doi: 10.1186/s13046-026-03657-y

    Figure Lengend Snippet: RGX-019-MMAE in combination with venetoclax enhanced AML cell killing. A , B Bar graphs show the absolute count of live leukemic cells in OCI-AML3 ( A ) and THP-1 ( B ) cell lines treated with indicated concentrations of venetoclax, RGX-019, and/or RGX-019-MMAE. Flow cytometry was used to determine the combinatorial effects of RGX-019-MMAE or monoclonal antibody RGX-019 with venetoclax. Annexin V-FITC was used as an apoptosis marker, and cell viability was determined with DAPI. (Welch one-way ANOVA) * p ≤0.05, ** p ≤0.01, *** p ≤0.001, **** p ≤0.0001

    Article Snippet: Kasumi-1, THP-1, MV4-11, and U937 AML cells were purchased from ATCC (Manassas, VA), and MOLM-13, MOLM-14, OCI-AML3, and OCI-AML2 cells were obtained from DSMZ (Braunschweig, Germany).

    Techniques: Flow Cytometry, Marker